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6-arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation.

Authors
Ryu, CK; Jung, SH; Lee, JA; Kim, HJ; Lee, SH; Chung, JH
Citation
Bioorganic & medicinal chemistry letters, 9(17):2469-2472, 1999
Journal Title
Bioorganic & medicinal chemistry letters
ISSN
0960-894X1464-3405
Abstract
6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.
MeSH terms
AnimalsAorta/drug effectsAorta/physiologyEndothelium, Vascular/drug effects*Endothelium, Vascular/physiologyMuscle Relaxation/drug effectsQuinolines/chemical synthesisQuinolines/chemistryQuinolines/pharmacology*RatsStructure-Activity Relationship
PMID
10498190
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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