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Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.

Authors
Jung, YS; Cho, TS; Moon, CH; Lee, B; Lee, SM; Shin, HS
Citation
Life sciences, 64(14):PL173-PL177, 1999
Journal Title
Life sciences
ISSN
0024-32051879-0631
Abstract
In this study, we investigated whether the systemically administered capsazepine can prevent the capsaicin-induced desensitization ex vivo in guinea-pig bronchi. Pretreatment with capsaicin (2.5, 5 and 10 mg/kg, s.c.) induced the functional desensitization and the loss of substance P-like immunoreactivity (SP-LI) with a similar potency (ED50: 3.31 +/- 0.57 and 4.81 +/- 0.89 mg/kg, respectively) in isolated guinea-pig bronchi. Capsazepine (30 mg/kg, s.c.) co-administered with capsaicin (5 mg/kg, s.c.) prevented the capsaicin (5 mg/kg, s.c.)-induced functional desensitization and loss of SP-LI. These results suggest that capsazepine can antagonize systemically the desensitizing action of capsaicin at the level of receptor, preventing the loss of SP-LI and the establishment of functional desensitization in guinea-pig bronchi.
MeSH terms
AnimalsBronchi/chemistryBronchi/drug effects*Capsaicin/analogs & derivatives*Capsaicin/antagonists & inhibitors*Capsaicin/pharmacologyDose-Response Relationship, DrugGuinea PigsMaleSubstance P/analysis*Substance P/immunology
PMID
10210268
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
정, 이숙문, 창현
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