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Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid.

DC Field Value Language
dc.contributor.authorHwang, SC-
dc.contributor.authorJhon, DY-
dc.contributor.authorBae, YS-
dc.contributor.authorKim, JH-
dc.contributor.authorRhee, SG-
dc.date.accessioned2011-09-02T01:30:19Z-
dc.date.available2011-09-02T01:30:19Z-
dc.date.issued1996-
dc.identifier.issn0021-9258-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4005-
dc.description.abstractPhospholipase C-gamma (PLC-gamma) isozymes are thought to be activated by receptor-induced tyrosine phosphorylation. Proteins that activate PLC-gamma1 have now been purified from bovine brain and identified as members of the tau family of microtubule-associated proteins. Activation of PLC-gamma by tau was enhanced in the presence of unsaturated fatty acids such as arachidonic acid, saturated fatty acids being ineffective. Maximal (15-20-fold) activation was apparent in the presence of 0.15 microM tau and 25 microM arachidonic acid (AA). The effect of tau and AA was specific to PLC-gamma isozymes in the presence of submicromolar concentrations of Ca2+ and was markedly inhibited by phosphatidylcholine. These results suggest that in cells that express tau, receptors coupled to cytosolic phospholipase A2 may activate PLC-gamma isozymes indirectly in the absence of tyrosine phosphorylation through the hydrolysis of phosphatidylcholine to generate AA.-
dc.language.isoen-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAnimals-
dc.subject.MESHArachidonic Acid/metabolism/*pharmacology-
dc.subject.MESHBrain/metabolism-
dc.subject.MESHCattle-
dc.subject.MESHCytosol/metabolism-
dc.subject.MESHEnzyme Activation/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHHydrolysis-
dc.subject.MESHIsoenzymes/*metabolism-
dc.subject.MESHKinetics-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHPhosphatidylinositol 4,5-Diphosphate-
dc.subject.MESHPhosphatidylinositol Phosphates/metabolism-
dc.subject.MESHPhosphatidylinositols/metabolism-
dc.subject.MESHPhospholipase C gamma-
dc.subject.MESHPhospholipases A/metabolism-
dc.subject.MESHPhospholipases A2-
dc.subject.MESHPhosphorylation-
dc.subject.MESHSubstrate Specificity-
dc.subject.MESHType C Phospholipases/*metabolism-
dc.subject.MESHTyrosine/metabolism-
dc.subject.MESHtau Proteins/genetics/metabolism/*pharmacology-
dc.titleActivation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid.-
dc.typeArticle-
dc.identifier.pmid8702475-
dc.identifier.urlhttp://www.jbc.org/cgi/pmidlookup?view=long&pmid=8702475-
dc.contributor.affiliatedAuthor황, 성철-
dc.type.localJournal Papers-
dc.citation.titleThe Journal of biological chemistry-
dc.citation.volume271-
dc.citation.number31-
dc.citation.date1996-
dc.citation.startPage18342-
dc.citation.endPage18349-
dc.identifier.bibliographicCitationThe Journal of biological chemistry, 271(31):18342-18349, 1996-
dc.identifier.eissn1083-351X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
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