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IGF-I of serum and vitreous fluid in patients with diabetic proliferative retinopathy.

Lee, HC; Lee, KW; Chung, CH; Chung, YS; Lee, EJ; Lim, SK; Kim, KR; Huh, KB; Lee, SC; Kwon, OW
Diabetes research and clinical practice, 24(2):85-88, 1994
Journal Title
Diabetes research and clinical practice
Vitreous fluid and serum were obtained at the time of vitrectomy from 15 subjects with diabetic proliferative retinopathy and 6 control subjects. The mean serum IGF-I (IGF-I level: 1 nM/l = 7.7 ng/ml) concentrations were 15.40 +/- 4.97 nM/l in controls and 16.24 +/- 4.32 nM/l in diabetic patients. The mean vitreous IGF-I concentration was 1.05 +/- 0.30 nM/l in controls and 0.91 +/- 0.50 nM/l in diabetic patients. There were no significant differences between the two groups, and serum IGF-I concentrations were not correlated with vitreous IGF-I concentrations in the patients with diabetic proliferative retinopathy. These data suggest that IGF-I may not be a risk factor for the development of proliferative diabetic retinpathy.
MeSH terms
AdultAgedBlood PressureDiabetic Retinopathy/blood/*physiopathology/surgeryHumansInsulin-Like Growth Factor I/analysis/*metabolismMiddle AgedRadioimmunoassayReference ValuesVitrectomyVitreous Body/*chemistry
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Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
정, 윤석
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