72 206

Cited 0 times in

Effect of nifedipine on renal allograft function and survival beyond one year.

Shin, GT; Cheigh, JS; Riggio, RR; Suthanthiran, M; Stubenbord, WT; Serur, D; Wang, JC; Rubin, AL; Stenzel, KH
Clinical nephrology, 47(1):33-36, 1997
Journal Title
Clinical nephrology
We previously reported that a calcium channel blocker supplemented immunosuppression produced excellent patient and graft survival rates in cadaveric kidney transplantation. We report here the long term outcome of patients treated with nifedipine-supplemented triple immunosuppression as compared with those of historical controls who were treated similarly without nifedipine. Study subjects included 111 patients transplanted in 1990-1994, treated with nifedipine and triple immunosuppression and with functioning grafts for more than one year (Nifedipine group). The results of cyclosporine (CyA) dose, blood pressure (BP), serum creatinine (Cr), and actuarial graft survival rate (GSR) up to 5 years posttransplant in these patients were compared with those of 52 patients transplanted in 1985-1990, treated similarly without calcium channel blockers (Control group). Donor sources, gender ratio, age distribution, causes of end stage renal disease, incidence of hypertension prior to transplantation and incidence of rejection in the first year between the groups were comparable. Throughout the study period the Nifedipine group had significantly lower serum Cr (1.5 +/- 0.7 vs. 1.8 +/- 0.7 mg/dl) and higher GSR (93.8% vs. 88% at 5 years) than the Control group. BP was comparable despite higher CyA doses in the Nifedipine group (4.3 +/- 1.1 vs. 3.3 +/- 1.1 mg/kg/day). We conclude that nifedipine is beneficial in improving long-term graft function and survival in kidney transplant recipients by mitigating CyA associated renal injury.
MeSH terms
AdultBlood Pressure/physiologyCalcium Channel Blockers/*therapeutic useCreatinine/bloodDrug Therapy, CombinationFemaleFollow-Up StudiesGraft Rejection/*physiopathology/prevention & controlGraft Survival/*physiologyHumansImmunosuppressive Agents/*therapeutic useKidney/drug effects/*physiologyKidney Transplantation/*physiologyMaleNifedipine/*therapeutic useProspective StudiesTransplantation, Homologous
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nephrology
AJOU Authors
신, 규태
Files in This Item:
Full-Text Not Available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.