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Concurrent presentation of erythrocytic and megakaryocytic aplasia.

Authors
Canavan, BF; Huhn, RD; Kim, HC; Kosmin, M; Sheay, W; Saidi, P
Citation
American journal of hematology, 51(1):68-72, 1996
Journal Title
American journal of hematology
ISSN
0361-86091096-8652
Abstract
A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postulated. Well-established molecular and genetic evidence, along with clinical observations, suggests that a relationship exists between the erythrocytic and megakaryocytic cell lines. This may be related to a common bipotential stem cell or common cell surface markers. This case provides strong clinical evidence to support this relationship.
MeSH terms
AdultAntibodies, Viral/analysisAutoimmune Diseases/pathologyBone Marrow/*pathologyCell LineageCyclophosphamide/therapeutic useCyclosporine/therapeutic useErythroid Precursor Cells/*pathologyFemaleHematopoiesisHepatitis B Surface Antigens/analysisHepatitis C Antibodies/analysisHumansImmunity, CellularImmunoglobulin G/analysisImmunoglobulins, Intravenous/therapeutic useImmunosuppressive Agents/therapeutic useMegakaryocytes/*pathologyParvovirus B19, Human/immunologyPlatelet TransfusionPrednisone/therapeutic useRed-Cell Aplasia, Pure/*complications/immunology/therapyThrombocytopenia/*complications/immunology/therapyVincristine/therapeutic use
DOI
10.1002/(SICI)1096-8652(199601)51:1<68::AID-AJH11>3.0.CO;2-7
PMID
8571940
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
김, 효철
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