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Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain.

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dc.contributor.authorLee, HR-
dc.contributor.authorKim, JH-
dc.contributor.authorUhm, HD-
dc.contributor.authorAhn, JB-
dc.contributor.authorRha, SY-
dc.contributor.authorCho, JY-
dc.contributor.authorLee, JI-
dc.contributor.authorLee, KH-
dc.contributor.authorChung, HC-
dc.contributor.authorRoh, JK-
dc.contributor.authorMin, JS-
dc.contributor.authorLee, KS-
dc.contributor.authorShin, DH-
dc.contributor.authorKim, BS-
dc.contributor.authorHong, SW-
dc.contributor.authorChoi, JH-
dc.date.accessioned2011-09-06T05:50:03Z-
dc.date.available2011-09-06T05:50:03Z-
dc.date.issued1996-
dc.identifier.issn0030-2414-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4038-
dc.description.abstractAn immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, erbB-2-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHSurvival Analysis-
dc.titleOverexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain.-
dc.typeArticle-
dc.identifier.pmid8643220-
dc.contributor.affiliatedAuthor최, 진혁-
dc.type.localJournal Papers-
dc.citation.titleOncology-
dc.citation.volume53-
dc.citation.number3-
dc.citation.date1996-
dc.citation.startPage192-
dc.citation.endPage197-
dc.identifier.bibliographicCitationOncology, 53(3). : 192-197, 1996-
dc.identifier.eissn1423-0232-
dc.relation.journalidJ000302414-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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