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Alpha-fetoprotein-producing gastric cancer.

Lee, R; Rha, SY; Ahn, JB; Shim, KY; Choi, JH; Lim, HY; Yoo, NC; Noh, SH; Kim, JH; Roh, JK; Min, JS; Kim, BS; Chung, HC
Oncology reports, 5(5):1179-1184, 1998
Journal Title
Oncology reports
We measured the sero-positivity rate of serum alpha-fetoprotein (alphaFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between alphaFP-positive and -negative patients. The overall synchronous hepatic metastasis rates in alphaFP-positive and alphaFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight alphaFP-positive patients were as follows: 37. 5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three alphaFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in alphaFP-negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in alphaFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, alphaFP can be used in predicting liver metastasis during follow-up.
MeSH terms
AdultAgedFemaleHumansLiver Neoplasms/blood/epidemiology/pathology/*secondaryMaleMiddle AgedNeoplasm MetastasisPalliative CarePrognosisStomach Neoplasms/*blood/mortality/*pathology/surgerySurvival RateTime Factorsalpha-Fetoproteins/*analysis/biosynthesis
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Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
최, 진혁임, 호영
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