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Occupational asthma due to deer dander.

Authors
Nahm, DH; Park, JW; Hong, CS
Citation
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 76(5):423-426, 1996
Journal Title
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN
1081-12061534-4436
Abstract
BACKGROUND: The literature on allergy to deer is limited. The allergenic component remains to be identified.



METHODS: We report a case of occupational asthma and rhinitis caused by deer dander. A 44-year-old male farmer had raised three red deer on his farm for 2 years, prior to occurrence of asthmatic symptoms. Dander extract was prepared from the patient's deer.



RESULTS: Skin-prick test elicited positive reactions to dander extracts from goat, sheep, camel, and cow as well as to deer dander extract. Bronchoprovocation test with deer dander extract elicited an early asthmatic response. Serum-specific IgE antibody to the deer dander extract was detected by enzyme-linked immunosorbent assay (ELISA). Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot analysis showed five IgE binding components (110, 72, 59, 45, and 21 kilodalton) within the deer dander extract.



CONCLUSIONS: These results suggest that deer dander can induce occupational asthma through an IgE-mediated mechanism in a farmer raising deer.
MeSH terms
AdultAllergens/*immunologyAnimalsAsthma/*etiologyBronchial Provocation TestsDeer/*immunologyElectrophoresis, Polyacrylamide GelFollow-Up StudiesHair/*immunologyHumansImmunoblottingImmunoglobulin E/analysisIntradermal TestsMaleOccupational Diseases/*etiology
DOI
10.1016/S1081-1206(10)63458-8
PMID
8630715
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
남, 동호
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