85 219

Cited 0 times in

Correlation between IgA antibody and eosinophil cationic protein levels in induced sputum from asthmatic patients.

Authors
Nahm, DH; Park, HS
Citation
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 27(6):676-681, 1997
Journal Title
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN
0954-78941365-2222
Abstract
BACKGROUND: Eosinophils are known to be main effector cells in allergic inflammation and IgA antibody has been shown to be a potent stimulus for eosinophil degranulation in in vitro conditions.



OBJECTIVE: To evaluate the possible role of IgA antibodies on eosinophil degranulation in lower respiratory mucosa of asthmatics, we tried to find a correlation between total IgA and eosinophil cationic protein (ECP) levels in induced sputum from asthmatics.



METHODS: We measured total IgA and albumin levels by nephelometry, and eosinophil cationic protein levels by Pharmacia CAP system in induced sputum from 23 atopic asthmatics and 12 healthy controls.



RESULTS: IgA and albumin levels in induced sputum from asthmatics with sputum eosinophilia (sputum eosinophil count > or = 5% of 200 counted non-squamous cells) were significantly higher (P 0.05). In induced sputum from asthmatics, ECP levels were significantly correlated with albumin (r = 0.44, P = 0.04) and IgA levels (r = 0.67, P = 0.002). ECP/albumin ratio was also significantly correlated with IgA/ albumin ratio (r = 0.61, P = 0.004).



CONCLUSION: Our results support the hypothesis that IgA antibodies in tracheobronchial secretion may be involved in eosinophil degranulation in asthma, and further study is needed to prove this hypothesis.
MeSH terms
AdultAlbumins/analysisAsthma/*immunologyBlood Proteins/*analysisEosinophil Granule ProteinsEosinophils/*chemistryFemaleHumansImmunoglobulin A/*analysisInflammation Mediators/*analysisMaleNephelometry and Turbidimetry*RibonucleasesSputum/*chemistry
PMID
9208189
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
남, 동호박, 해심
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse