82 262

Cited 8 times in

Biological monitoring of tetrahydrofuran: contribution of a physiologically based pharmacokinetic model.

Authors
Droz, PO; Berode, M; Jang, JY
Citation
American Industrial Hygiene Association journal, 60(2):243-248, 1999
Journal Title
American Industrial Hygiene Association journal
ISSN
0002-8894
Abstract
A seven-compartment physiologically based pharmacokinetic (PBPK) model was developed to predict biological levels of tetrahydrofuran under various exposure scenarios. Affinities for the tissue were estimated from measurements of liquid-gas partition coefficients for water, olive oil, and blood. Metabolism was assumed to follow a rapid first order reaction. urinary excretion was simulated considering passive reabsorption of tetrahydrofuran in the tubules. The validity of the model was tested by comparison with available experimental and field data. Agreement was satisfactory with all studies available except one, which showed much higher results than expected. The source of this difference could not be identified, but cannot be explained by different exposure conditions, such as duration, concentration, or physical work load. However, it is recommended that this particular study not be used in the establishment of a biological exposure index. Simulation of repeated occupational exposure with the PBPK model allowed the prediction of biological levels that would be reached after repeated exposure at the American Conference of Governmental Industrial Hygienists' threshold limit value, time-weighted average of 200 ppm. For samples taken at the end of the shift, the PBPK model predicts 5.1 ppm for breath, 57 mumol/L (4.1 mg/L) for venous blood, and 100 mumol/L (7.2 mg/L) for urine.
MeSH terms
Environmental Monitoring/methods*Furans*/analysisFurans*/metabolismFurans*/pharmacokineticsGlomerular Filtration RateHumansKidney Tubules/physiologyMaximum Allowable ConcentrationModels, Chemical*Occupational Exposure/analysis*OccupationsPredictive Value of TestsReproducibility of ResultsTime FactorsWorkload
DOI
10.1080/00028899908984443
PMID
10222575
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
장, 재연
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse