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Application of biological monitoring to the quantitative exposure assessment for neuropsychological effect by chronic exposure to organic solvents.

Jang, JY  | Lee, SY | Kim, JI | Park, JB | Lee, KJ | Chung, HK
International archives of occupational and environmental health, 72(2). : 107-114, 1999
Journal Title
International archives of occupational and environmental health
OBJECTIVE: Quantitative exposure assessment became more common as a result of attempts to reduce nondifferential exposure misclassification and to observe a steeper exposure-response relationship. Several exposure variables were compared in a demonstration of the exposure-response relationship between neuropsychological abnormality and long-term exposure to organic solvents in workers at one shipyard.

METHOD: Environmental monitoring and biological monitoring were performed to evaluate the exposure of the workers to organic solvents. Cumulative exposure (CE) and lifetime-weighted average exposure variables were developed with both environmental and biological monitoring data. A neuropsychological questionnaire and a function test for confirmation of a disorder or dysfunction in attention, executive function, visuospatial, and constructional abilities, learning and memory, and psychomotor function were performed.

RESULTS: The abnormal rate in neuropsychological diagnosis was 9.3% in the exposed group, which was much higher than the 2.1% rate obtained in the nonexposed group (P<0.01). The neuropsychological abnormal rate showed a significant dose-response association with CE created with biological monitoring data. The results also suggest that biological monitoring can provide impressive and effective information for quantitative exposure assessment, even in epidemiology studies.

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Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Ajou Authors
장, 재연
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