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Attenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures.

DC Field Value Language
dc.contributor.authorNoh, JS-
dc.contributor.authorGwag, BJ-
dc.date.accessioned2011-09-08T01:36:32Z-
dc.date.available2011-09-08T01:36:32Z-
dc.date.issued1997-
dc.identifier.issn0014-4886-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4094-
dc.description.abstractEvents which lead to an increase in intracellular free radicals induce necrotic cell death of cultured cortical neurons. In the present study, we report that treatment with 1 microM (+/-)-SKF-38393 hydrochloride, a selective D1 agonist, as well as 100 microM trolox, a lipophilic vitamin E analogue, significantly prevented oxidative-related necrotic cell death following exposure to 10 microM Fe2+ or 1 mM buthionine sulfoximine, an inhibitor of gamma-glutamylcysteine synthetase. The neuroprotective effect of (+/-)-SKF-38393 hydrochloride was partially reversed by addition of (+/-)-SKF-83566 hydrochloride, a selective D1 antagonist. Quinelorane dihydrochloride, a selective D2 agonist, did not influence free radical neurotoxicity. Interestingly, inclusion of (+/-)-SKF-38393 hydrochloride or quinelorane dihydrochloride did not attenuate apoptotic cell death of cortical neurons deprived of serum. The present study provides evidence that (+/-)-SKF-38393 hydrochloride attenuates oxidative neuronal necrosis, which has unique therapeutic potential for the treatment of various neurodegenerative diseases linked to oxidative stress.-
dc.language.isoen-
dc.subject.MESH2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/analogs & derivatives/*pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/pharmacology-
dc.subject.MESHApoptosis-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex/drug effects/*metabolism/*pathology-
dc.subject.MESHChromans/pharmacology-
dc.subject.MESHCulture Media, Serum-Free/pharmacology-
dc.subject.MESHDopamine Agonists/*pharmacology-
dc.subject.MESHDopamine Antagonists/pharmacology-
dc.subject.MESHMice/embryology-
dc.subject.MESHNecrosis-
dc.subject.MESHNeurons/*drug effects/*pathology-
dc.subject.MESHNeuroprotective Agents/*pharmacology-
dc.subject.MESHOxidation-Reduction-
dc.subject.MESHReceptors, Dopamine D1/*agonists-
dc.subject.MESHVitamin E/analogs & derivatives-
dc.titleAttenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures.-
dc.typeArticle-
dc.identifier.pmid9270075-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014-4886(97)96569-9-
dc.contributor.affiliatedAuthor노, 재성-
dc.contributor.affiliatedAuthor곽, 병주-
dc.type.localJournal Papers-
dc.identifier.doi10.1006/exnr.1997.6569-
dc.citation.titleExperimental neurology-
dc.citation.volume146-
dc.citation.number2-
dc.citation.date1997-
dc.citation.startPage604-
dc.citation.endPage608-
dc.identifier.bibliographicCitationExperimental neurology, 146(2):604-608, 1997-
dc.identifier.eissn1090-2430-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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