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Occupational asthma and IgE sensitization to cellulase in a textile industry worker.

Authors
Kim, HY; Nahm, DH; Park, HS; Choi, DC
Citation
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 82(2):174-178, 1999
Journal Title
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN
1081-12061534-4436
Abstract
BACKGROUND: Although there have been a few reports of occupational asthma due to cellulase in several occupational settings, this is the first case of cellulase-induced occupational asthma in an employee working in the textile industry. Its pathogenetic mechanism remains to be further clarified.



OBJECTIVE: It is important to alert physicians to the possibility of occupational asthma caused by cellulase in workers of the textile industry.



METHODS AND RESULTS: The patient had atopy and strong positive responses to cellulase extract on skin prick tests. Bronchoprovocation test showed an early asthmatic response to cellulase extract. Serum specific IgE and specific IgG4 antibodies to cellulase were detected by enzyme-linked immunosorbent assay (ELISA). In order to further characterize the allergenic component of the extract, sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were performed. Eight IgE binding components ranging from 6 to 97.5 kD were detected within the cellulase extract.



CONCLUSION: These findings suggest that inhalation of cellulase can induce IgE-mediated bronchoconstrictions in employees working in the textile industry.
MeSH terms
AdultAntibodies, Fungal/bloodAntibodies, Fungal/immunologyAntibody SpecificityAsthma/chemically induced*Bronchial Provocation TestsCellulase/adverse effects*Cellulase/immunologyFungal Proteins/adverse effects*Fungal Proteins/immunologyHumansHypersensitivity, Immediate/complicationsImmunoglobulin E/blood*Immunoglobulin G/bloodImmunoglobulin G/immunologyMaleMethacholine Chloride/diagnostic useOccupational Diseases/chemically induced*Skin TestsTextile Industry*
DOI
10.1016/S1081-1206(10)62593-8
PMID
10071521
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
남, 동호박, 해심
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