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Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.

DC Field Value Language
dc.contributor.authorTada, A-
dc.contributor.authorSuzuki, I-
dc.contributor.authorIm, S-
dc.contributor.authorDavis, MB-
dc.contributor.authorComelius, J-
dc.contributor.authorBabcock, G-
dc.contributor.authorNordlund, JJ-
dc.contributor.authorAbdel-Malek, ZA-
dc.date.accessioned2011-09-08T02:21:11Z-
dc.date.available2011-09-08T02:21:11Z-
dc.date.issued1998-
dc.identifier.issn1044-9523-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4107-
dc.description.abstractEndothelin (ET)-1, alpha-melanocyte stimulating hormone (alpha-melanotropin; alpha-MSH), and basic fibroblast growth factor (bFGF) are keratinocyte-derived factors that interact synergistically to stimulate human melanocyte proliferation. ET-1 has a dose-dependent mitogenic effect on human melanocytes and a biphasic effect on melanogenesis: a stimulatory effect at subnanomolar concentrations, and an inhibitory effect at concentrations equal to or higher than 1 nM. Human melanocytes express ET B receptors. Brief treatment of melanocytes with ET-1 caused up-regulation of alpha-MSH receptor mRNA but did not alter ET B receptor mRNA level. ET-1 modulates the response of human melanocytes to UV rays (UVRs). Treatment of melanocytes with 10 nM ET-1 immediately after exposure to UVRs enabled them to overcome the G1 growth arrest. However, ET-1 did not inhibit p53 accumulation or p21(Waf-1/SDI-1/Cip-1) overexpression, nor did it reverse the hypophosphorylated state of pRb or the reduction in Bcl2 level in irradiated melanocytes. These results substantiate the role of ET-1 as a paracrine regulator that modulates the response of human melanocytes to UVRs.-
dc.language.isoen-
dc.subject.MESHCell Division-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEndothelin-1-
dc.subject.MESHEndothelin-3-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenes, bcl-2-
dc.subject.MESHHumans-
dc.subject.MESHMelanocytes-
dc.subject.MESHMitogens-
dc.subject.MESHParacrine Communication-
dc.subject.MESHRadiation Tolerance-
dc.subject.MESHReceptor, Endothelin B-
dc.subject.MESHReceptors, Corticotropin-
dc.subject.MESHReceptors, Endothelin-
dc.subject.MESHReceptors, Melanocortin-
dc.subject.MESHTumor Suppressor Protein p53-
dc.subject.MESHUltraviolet Rays-
dc.subject.MESHalpha-MSH-
dc.titleEndothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.-
dc.typeArticle-
dc.identifier.pmid9690625-
dc.identifier.urlhttp://cgd.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9690625-
dc.contributor.affiliatedAuthor임, 성빈-
dc.type.localJournal Papers-
dc.citation.titleCell growth and differentiation-
dc.citation.volume9-
dc.citation.number7-
dc.citation.date1998-
dc.citation.startPage575-
dc.citation.endPage584-
dc.identifier.bibliographicCitationCell growth and differentiation, 9(7). : 575-584, 1998-
dc.relation.journalidJ010449523-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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