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Cited 8 times in

Widely varying TNF-alpha levels in patients with myasthenia gravis.

DC Field Value Language
dc.contributor.authorLee, JS-
dc.contributor.authorJoo, IS-
dc.contributor.authorSeok, JI-
dc.date.accessioned2010-12-06T01:36:36Z-
dc.date.available2010-12-06T01:36:36Z-
dc.date.issued2009-
dc.identifier.issn1590-1874-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/412-
dc.description.abstractAnimal studies have indicated an important role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of myasthenia gravis (MG), and trials of monoclonal antibodies that block TNF-alpha have shown clinical improvement. However, before a TNF-alpha blocking agent is proposed for treatment of MG, whether serum TNF-alpha level correlates with the patient's condition should be confirmed. Therefore, we evaluated the relationship between the serum TNF-alpha level and clinical factors, including the quantitative MG score and the anti-acetylcholine receptor antibody level, in 33 MG patients. TNF-alpha levels ranged from 0.44 to 3.63 pg/mL and did not correlate with clinical factors. Overall, we found that serum TNF-alpha levels varied greatly among MG patients.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAutoantibodies/blood*-
dc.subject.MESHAutoantibodies/immunology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyasthenia Gravis/blood*-
dc.subject.MESHMyasthenia Gravis/drug therapy-
dc.subject.MESHMyasthenia Gravis/immunology-
dc.subject.MESHReceptors, Nicotinic/immunology*-
dc.subject.MESHReference Values-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTumor Necrosis Factor-alpha/blood*-
dc.titleWidely varying TNF-alpha levels in patients with myasthenia gravis.-
dc.typeArticle-
dc.identifier.pmid19214380-
dc.contributor.affiliatedAuthor이, 진수-
dc.contributor.affiliatedAuthor주, 인수-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s10072-009-0023-0-
dc.citation.titleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology-
dc.citation.volume30-
dc.citation.number3-
dc.citation.date2009-
dc.citation.startPage259-
dc.citation.endPage262-
dc.identifier.bibliographicCitationNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 30(3):259-262, 2009-
dc.identifier.eissn1590-3478-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology

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