Cited 0 times in Scipus Cited Count

Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines.

DC Field Value Language
dc.contributor.authorSoh, EY-
dc.contributor.authorSobhi, SA-
dc.contributor.authorWong, MG-
dc.contributor.authorMeng, YG-
dc.contributor.authorSiperstein, AE-
dc.contributor.authorClark, OH-
dc.contributor.authorDuh, QY-
dc.date.accessioned2011-09-14T01:25:28Z-
dc.date.available2011-09-14T01:25:28Z-
dc.date.issued1996-
dc.identifier.issn0039-6060-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4132-
dc.description.abstractBACKGROUND: Vascular endothelial growth factor (VEGF) is a vascular endothelial cell-specific mitogen secreted by some cancer cells and is a major regulator of angiogenesis. Because thyroid-stimulating hormone (TSH) promotes growth and progression of thyroid cancers, we postulated that TSH may increase the production and secretion of VEGF by thyroid cancer cells.



METHODS: We examined primary cultures of normal human thyroid (NT 1.0), medullary thyroid cancer (MTC 1.1), and cell lines derived from the papillary (TPC-1), follicular (FTC-133), and Hürthle cell (XTC-1) thyroid cancer. We quantified the concentration of VEGF in conditioned medium by means of enzyme-linked immunosorbent assay.



RESULTS: Cell lines derived from thyroid secrete VEGF. Basal VEGF secretion was similar in normal and thyroid cancer cells, except XTC-1, which has high basal secretion (p < 0.01). All thyroid cancer cells secrete significantly more VEGF than normal thyroid cells after TSH (10 mIU/ml) stimulation (p < 0.05). TSH stimulated secretion of VEGF in FTC-133 (8.2 ng/dl versus 18.8 ng/dl), TPC-1 (5.5 ng/dl versus 26.9 ng/dl), and MTC 1.1 (5.9 ng/dl versus 13.4 ng/dl) cell lines (p < 0.01), but not in NT 1.0 (8.4 ng/dl versus 9.9 ng/dl) and XTC-1 (25.4 ng/dl versus 31.2 ng/dl) cells.



CONCLUSIONS: These results suggest that VEGF secretion is constitutively activated in some thyroid cancers and that VEGF secretion is stimulated by TSH; thus TSH may promote growth in some thyroid cancers by stimulating VEGF secretion and angiogenesis.
-
dc.language.isoen-
dc.subject.MESHEndothelial Growth Factors-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHHumans-
dc.subject.MESHLymphokines-
dc.subject.MESHReference Values-
dc.subject.MESHThyroid Gland-
dc.subject.MESHThyroid Neoplasms-
dc.subject.MESHThyrotropin-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHVascular Endothelial Growth Factor A-
dc.subject.MESHVascular Endothelial Growth Factors-
dc.titleThyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines.-
dc.typeArticle-
dc.identifier.pmid8957478-
dc.contributor.affiliatedAuthor소, 의영-
dc.type.localJournal Papers-
dc.citation.titleSurgery-
dc.citation.volume120-
dc.citation.number6-
dc.citation.date1996-
dc.citation.startPage944-
dc.citation.endPage947-
dc.identifier.bibliographicCitationSurgery, 120(6). : 944-947, 1996-
dc.identifier.eissn1532-7361-
dc.relation.journalidJ000396060-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse