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Signal transduction pathway in human middle ear cholesteatoma.

Authors
Myers, EN; Park, K; Chun, Y; Lee, D; Hwang, S
Citation
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 120(6):899-904, 1999
Journal Title
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN
0194-59981097-6817
Abstract
Phospholipase C-gamma1 plays a central role in signal transduction, and it is important in cellular growth, differentiation, and proliferation. Human cholesteatoma in the middle ear is characterized by the presence of a keratinizing epithelium that is believed to have hyperproliferative properties. The purpose of this study is to elucidate the distribution of phospholipase C-gamma1 in cholesteatoma matrix and deep meatal skin with Western blot analysis and immunohistochemistry. In conclusion, overexpression of phospholipase C-gamma1 in cholesteatoma matrix suggests a possible derangement of enhanced growth signal transduction in keratinocytes.
MeSH terms
Antibodies, MonoclonalBlotting, WesternCell DivisionCholesteatoma, Middle Ear/physiopathology*HumansImmunoblottingImmunohistochemistryKeratinocytes/physiologySignal Transduction*Type C Phospholipases/metabolism*
DOI
10.1016/S0194-5998(99)70334-7
PMID
10352447
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
박, 기현전, 영명황, 성철
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