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Prognostic significance of ST-segment depression during adenosine perfusion imaging.

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dc.contributor.authorMarshall, ES-
dc.contributor.authorRaichlen, JS-
dc.contributor.authorKim, SM-
dc.contributor.authorIntenzo, CM-
dc.contributor.authorSawyer, DT-
dc.contributor.authorBrody, EA-
dc.contributor.authorTighe, DA-
dc.contributor.authorPark, CH-
dc.date.accessioned2011-09-19T03:53:38Z-
dc.date.available2011-09-19T03:53:38Z-
dc.date.issued1995-
dc.identifier.issn0002-8703-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4204-
dc.description.abstractTo determine the significance of ST-segment depression during adenosine perfusion imaging for predicting future cardiac events, 188 patients with interpretable electrocardiograms were assessed 1 to 3 years (mean 21.5 +/- 6.6 months) after adenosine testing. At least 1 mm of ST-segment depression was observed in 32 (17%) patients, with > or = 2 mm of ST-segment depression in 10 (5.3%). Thirty-seven cardiac events occurred during the study period: 2 cardiac deaths, 5 nonfatal myocardial infarctions, 6 admissions for unstable angina, and 24 revascularizations. Univariate predictors of events were a history of congestive heart failure, previous non-Q-wave myocardial infarction, previous coronary angioplasty, use of antianginal medication, ST-segment depression during adenosine infusion (particularly > or = 2 mm), any reversible perfusion defect, transient left ventricular cavity dilation, and the severity of perfusion defects. Multivariate analysis identified > or = 2 mm ST-segment depression as the most significant predictor of cardiac events (relative risk [RR] = 6.5; p = 0.0001). Other independent predictors of events were left ventricular dilation (RR = 3.8; p = 0.002), previous coronary angioplasty (RR = 3.3; p = 0.001), a history of non-Q-wave myocardial infarction (RR = 2.3; p = 0.01), and the presence of any reversible defect (RR = 2.0; p = 0.05). We conclude that ST-segment depression occurs uncommonly during adenosine infusion, but the presence of > or = 2 mm of ST-segment depression is an independent predictor of future cardiac events and provides information in addition to that obtained from clinical variables and the results of adenosine perfusion imaging.-
dc.language.isoen-
dc.subject.MESHAdenosine/administration & dosage/*diagnostic use-
dc.subject.MESHAged-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCoronary Disease/diagnosis-
dc.subject.MESHCoronary Vessels/radionuclide imaging-
dc.subject.MESHElectrocardiography/*drug effects/methods/statistics & numerical data-
dc.subject.MESHExercise Test/methods/statistics & numerical data-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLikelihood Functions-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHTechnetium Tc 99m Sestamibi/diagnostic use-
dc.subject.MESHThallium Radioisotopes/diagnostic use-
dc.subject.MESHTime Factors-
dc.titlePrognostic significance of ST-segment depression during adenosine perfusion imaging.-
dc.typeArticle-
dc.identifier.pmid7611124-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/0002-8703(95)90236-8-
dc.contributor.affiliatedAuthor박, 찬희-
dc.type.localJournal Papers-
dc.citation.titleAmerican heart journal-
dc.citation.volume130-
dc.citation.number1-
dc.citation.date1995-
dc.citation.startPage58-
dc.citation.endPage66-
dc.identifier.bibliographicCitationAmerican heart journal, 130(1):58-66, 1995-
dc.identifier.eissn1097-6744-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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