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Multiple brown tumors in parathyroid carcinoma mimicking metastatic bone disease.

Pai, M; Park, CH; Kim, BS; Chung, YS; Park, HB
Clinical nuclear medicine, 22(10):691-694, 1997
Journal Title
Clinical nuclear medicine
An unusual case of multiple brown tumors due to parathyroid carcinoma is reported. The patient presented with lower leg pain. Plain radiographs demonstrated multiple lytic lesions of the lower legs and a Tc-99m MDP bone scan depicted multiple areas of increased uptake suggesting skeletal metastases. Tc-99m sestamibi tumor scintigraphy showed multiple sites of tumor uptake in bones and a large area of increased uptake with a cystic component in the right lower pole of the thyroid gland. An open biopsy from the right tibial lesion revealed a brown tumor. A large parathyroid carcinoma with a necrotic cyst was removed. After parathyroidectomy and right thyroid lobectomy, the patient became free of bone pain and serum PTH levels normalized. A 9-month follow-up Tc-99m MDP bone scan demonstrated less intense uptake in the pelvis, tibia, and fibulae. Nine-month follow-up tumor imaging with Tc-99m MIBI revealed disappearance of the preoperative uptake of multiple brown tumor.
MeSH terms
AdultBone Diseases/etiology/*radionuclide imagingBone Neoplasms/radionuclide imaging/*secondaryCarcinoma/complications/radionuclide imaging/*secondaryFemaleFollow-Up StudiesGranuloma, Giant Cell/etiology/*radionuclide imagingHumansHyperparathyroidism/diagnosis/etiologyLegOsteitis Fibrosa Cystica/etiology/*radionuclide imagingParathyroid Hormone/bloodParathyroid Neoplasms/*complicationsParathyroidectomyRadiopharmaceuticals/diagnostic useTechnetium Tc 99m Medronate/diagnostic useTechnetium Tc 99m Sestamibi/diagnostic useThyroid Gland/radionuclide imagingThyroidectomyWhole-Body Counting
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
박, 찬희김, 병석정, 윤석박, 희붕
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