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Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.

Authors
Kim, W  | Tang, Y | Okada, Y | Torrey, TA | Chattopadhyay, SK | Pfleiderer, M | Falkner, FG | Dorner, F | Choi, W | Hirokawa, N | Morse, HC 3rd
Citation
Journal of virology, 72(8). : 6898-6901, 1998
Journal Title
Journal of virology
ISSN
0022-538X1098-5514
Abstract
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
MeSH

PMID
9658142
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Ajou Authors
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