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Behçet's disease-like symptoms induced by the Herpes simplex virus in ICR mice.

Authors
Sohn, S; Lee, ES; Bang, D; Lee, S
Citation
European journal of dermatology : EJD, 8(1):21-23, 1998
Journal Title
European journal of dermatology : EJD
ISSN
1167-11221952-4013
Abstract
Herpes simplex virus (HSV) infection has been suggested to be one of the etiologic or triggering factors in Behçet's disease. To test this hypothesis, 258 ICR mice were inoculated with HSV type 1 (KOS strain). After the induced infection, 86 mice (33.3%) died, 77 (29. 8%) showed Behçet's disease-like symptoms, and 95 (36.8%) had a healthy, normal appearance or just a single symptom. The symptoms included skin ulcers on the earlobe, neck, abdomen, back or face (57. 1%); eye syndromes (39.0%); partial hair loss (33.8%); genital ulcers (19.5%); bullae (11.7%); arthritis (5.2%); gastrointestinal ulcer (5.2%); and tongue ulcers (3.9%). The induced Behçet's disease-like symptoms are similar to the clinical manifestations of ulcers, uveitis, and arthritis which have been significant in diagnosing Behçet's disease in patients.
MeSH terms
AnimalsBehcet Syndrome/*pathology/*virologyDNA, Viral/analysisDisease Models, AnimalHerpes Simplex/*complicationsMiceMice, Inbred ICRPolymerase Chain ReactionReference ValuesSimplexvirus/isolation & purificationSkin/*pathology/*virologySurvival Rate
PMID
9649665
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
손, 성향이, 은소이, 성낙
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