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Endothelin-induced changes in intracellular calcium in human microglia.

Authors
McLarnon, JG; Wang, X; Bae, JH; Kim, SU
Citation
Neuroscience letters, 263(1):9-12, 1999
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Calcium-sensitive spectrofluorometry was used to study the effects of endothelin on levels of intracellular calcium [Ca2+]i in cultured human microglia. Both ET-1 and ET-3 induced transient, non-desensitizing, increases in [Ca2+]i in over 80% of the cells studied. The responses to either ET-1 or ET-3 were significantly diminished in amplitude and duration in Ca2+-free solution suggesting a prominent contribution of Ca2+ influx to the response. ET-1 induced changes in [Ca2+]i were not altered in the presence of the selective ET(A) antagonist BQ610 but were significantly reduced with the selective ET(B) antagonist BQ780. These results confirm the expression of ET(B) receptors on human microglia, these receptors may serve a role in a signaling pathway between microglia and endothelial cells.
MeSH terms
Brain/metabolismCalcium/metabolism*Cells, CulturedEndothelin-1/pharmacology*Endothelin-3/pharmacology*FetusHumansMicroglia/cytologyMicroglia/drug effectsMicroglia/metabolism*Oligopeptides/pharmacologyReceptors, Endothelin/antagonists & inhibitors
PMID
10218898
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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