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Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment.

Authors
Lee, KS; Chung, JH; Lee, KH; Shin, MJ; Oh, BH; Lee, SH; Hong, CH
Citation
Cellular & molecular immunology, 6(2):143-147, 2009
Journal Title
Cellular & molecular immunology
ISSN
1672-76812042-0226
Abstract
A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (beta-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and beta-NGF may be useful in differentiating subtypes of MCI.
MeSH terms
AgedAmnesia/bloodAmnesia/diagnosisAmnesia/immunology*Biological Markers/blood*Chemokine CCL7/blood*Cognition Disorders/bloodCognition Disorders/immunology*Diagnosis, DifferentialFemaleHumansMaleNerve Growth Factor/blood*Psychological TestsSeverity of Illness Index
DOI
10.1038/cmi.2009.20
PMID
19403065
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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