117 403

Cited 0 times in

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice.

DC Field Value Language
dc.contributor.authorVeinbergs, I-
dc.contributor.authorJung, MW-
dc.contributor.authorYoung, SJ-
dc.contributor.authorVan Uden, E-
dc.contributor.authorGroves, PM-
dc.contributor.authorMasliah, E-
dc.date.accessioned2011-09-22T04:37:12Z-
dc.date.available2011-09-22T04:37:12Z-
dc.date.issued1998-
dc.identifier.issn0304-3940-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4246-
dc.description.abstractRecent studies suggest that apolipoprotein E (apoE) plays a neurotrophic role in the central nervous system and that an aberrant function of this molecule might result in neurodegeneration. Supporting this notion, apoE-deficient mice show neurodegenerative and cognitive alterations. To characterize physiological changes associated with synaptic damage and cognitive impairment in apoE-deficient mice, we investigated synaptic plasticity in the hippocampus of urethane anesthetized mice. Electrical stimulation was delivered to the perforant pathway and the resulting evoked field excitatory postsynaptic potential (EPSP) and population spike were recorded in the hilus. Long-term potentiation, as measured in the population spike, was reduced by 50% in apoE-deficient mice when compared to wild-type controls. In contrast, there were no significant differences in the evoked field EPSP between wild-type and apoE-deficient mice following high-frequency stimulation. These results support the notion that cognitive impairment and synaptic loss in the hippocampus of apoE-deficient mice might be associated with impaired long-term potentiation.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHApolipoproteins E/genetics/*physiology-
dc.subject.MESHBrain Mapping-
dc.subject.MESHExcitatory Postsynaptic Potentials-
dc.subject.MESHHippocampus/*physiology-
dc.subject.MESH*Long-Term Potentiation-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.titleAltered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice.-
dc.typeArticle-
dc.identifier.pmid9682819-
dc.contributor.affiliatedAuthor정, 민환-
dc.type.localJournal Papers-
dc.citation.titleNeuroscience letters-
dc.citation.volume249-
dc.citation.number2-3-
dc.citation.date1998-
dc.citation.startPage71-
dc.citation.endPage74-
dc.identifier.bibliographicCitationNeuroscience letters, 249(2-3):71-74, 1998-
dc.identifier.eissn1872-7972-
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse