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Cholinergic agonists increase intracellular Ca2+ in cultured human microglia.

Authors
Zhang, L; McLarnon, JG; Goghari, V; Lee, YB; Kim, SU; Krieger, C
Citation
Neuroscience letters, 255(1):33-36, 1998
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Microglia are resident phagocytic cells in the central nervous system (CNS), and can be activated in response to various stimuli including neurotransmitters. Using fura-2 imaging, we investigated the effects of carbachol (CCh), a cholinergic agonist, on [Ca2+]i in cultured human microglia. Treatment of microglia with CCh (100 microM) produced a transient increase in [Ca2+]i, which was atropine-sensitive and was associated with release from intracellular Ca2+ stores. Successive applications of CCh showed a change in the amplitude of the [Ca2+]i signal consistent with desensitization. These results show that human microglia express functional muscarinic receptors and respond to cholinergic agonists. The rapid change of [Ca2+]i in microglia may serve as a second messenger to trigger downstream cascades which contribute to signalling pathways in CNS pathology.
MeSH terms
Atropine/pharmacologyCalcium/*metabolismCarbachol/administration & dosage/*pharmacologyCells, CulturedCholinergic Agonists/administration & dosage/*pharmacologyDrug Administration ScheduleDrug CombinationsFetusHumansIntracellular Membranes/*metabolismMicroglia/*drug effects/*metabolismMuscarinic Antagonists/pharmacologyOsmolar Concentration
PMID
9839720
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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