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Simultaneous measurement of 23 plasma cytokines in late-life depression.

Authors
Lee, KS; Chung, JH; Lee, KH; Shin, MJ; Oh, BH; Lee, SH; Hong, CH
Citation
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 30(5):435-438, 2009
Journal Title
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN
1590-18741590-3478
Abstract
According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1alpha) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1alpha levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1alpha may play important roles in the pathogenesis of late-life depression.
MeSH terms
AgedAged, 80 and overCytokines/blood*Depression/blood*FemaleHumansMaleMiddle AgedPlasma/metabolism*
DOI
10.1007/s10072-009-0091-1
PMID
19484185
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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