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Peripheral cytokines and chemokines in Alzheimer's disease.

Authors
Lee, KS; Chung, JH; Choi, TK; Suh, SY; Oh, BH; Hong, CH
Citation
Dementia and geriatric cognitive disorders, 28(4):281-287, 2009
Journal Title
Dementia and geriatric cognitive disorders
ISSN
1420-80081421-9824
Abstract
A chronic inflammatory process has been implicated in the neuropathology of Alzheimer's disease (AD). The present review focuses on the current knowledge of circulating serum and plasma biomarkers of AD that are linked to inflammatory reactions. There is abundant evidence that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Interleukins 1, 4, 6, 10, 12, 16, and 18, tumour necrosis factor, and several chemokines have been suggested as biomarkers of AD. Nonetheless, data on circulating cytokine levels are somewhat inconsistent with regard to peripheral cytokine dysregulation in AD. In summary, definite statements concerning differences in inflammatory biomarkers between controls and AD patients will require the use of sensitive multiplex assays in large patient groups in conjunction with measures of disease severity.
MeSH terms
Alzheimer Disease/metabolism*Alzheimer Disease/pathologyBiological MarkersChemokines/bloodChemokines/cerebrospinal fluidChemokines/metabolism*Cytokines/bloodCytokines/cerebrospinal fluidCytokines/metabolism*HumansInflammation/pathology
DOI
10.1159/000245156
PMID
19828948
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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