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Prognostic Factors in Transitional Cell Carcinoma of Upper Urinary Tract after Radical Nephroureterectomy

Other Title
근치적 신요관전적출술을 시행받은 상부요로 이행세포암에서 예후인자
Authors
김, 영균
Department
대학원 의학과
Degree
Master (2011)
Abstract
Purpose : The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC).

Materials and Methods : I retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed using univariate and multivariate analysis.

Results : Of total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. On univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. On multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival.

Conclusions : The T stage and LVI are independent prognostic factors for recurrence-free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding the decisions about adjuvant therapies and surveillance interval.
Keywords

Appears in Collections:
Theses > School of Medicine / Graduate School of Medicine > Master
Ajou Authors
김, 영균
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