Cadmium-induced COX-2 Expression in Cerebrovascular Endothelial Cells
카드뮴이 뇌혈관 내피세포에서의 및 COX-2 발현에 미치는 영향
박, 동현; 정, 이숙; 이, 수환; 백, 은주; 문, 창현; 김, 영채; 문, 창규
Journal of environmental toxicology, 21(3):275-282, 2006
Journal of environmental toxicology; 환경독성학회지
In order to get insight into the mechanism of cadmium (Cd)-induced brain injury, we investigated the effects of Cd on the induction of COX-2 in bEnd.3 mouse brain endothelial cells. Cd induced COX-2 expression and release, which were attenuated by thiol-reducing antioxidant N-acetylcysteine (NAC) indicating oxidative components might contribute to these events. Indeed, Cd increased cellular reactive oxygen species (ROS) level and DNA binding activity of nuclear factor-kB (NF-kB), an oxidative stress sensitive transcription factor. Cd-induced production and COX-2 expression were significantly attenuated by Bay 11 7082, a specific inhibitor of NF-kB and by SB203580, a specific inhibitor of p38 mitogen activated protein kinase (MAPK). These data suggest that Cd induces COX-2 expression through activation of NF-kB and p38 MAPK, the oxidative stress-sensitive signaling molecules, in brain endothelial cells.
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