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The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer.

Authors
Park, SY; Kim, KS; Lee, TG; Park, SS; Kim, SM; Han, W; Noh, DY; Kim, SW
Citation
American journal of surgery, 197(2):266-269, 2009
Journal Title
American journal of surgery
ISSN
0002-96101879-1883
Abstract
BACKGROUND: Proper determination of histologic type and biomarkers in a core biopsy specimen is important before preoperative systemic therapy. The purpose of this study was to determine the accuracy of preoperative core biopsy through comparative analysis of histologic grade (HG), hormone receptors, and human epidermal growth factor receptor 2 (HER-2) status in both the core biopsy and surgical specimens.



METHODS: We identified 104 patients with invasive ductal cancer who underwent core biopsy and definitive surgery in our institution. The histologic type, HG, estrogen receptor (ER), progesterone receptor (PR), and HER-2 status were determined in both the core biopsy and surgical specimens by one pathologist.



RESULTS: The mean age of the 104 patients was 50 +/- 9.9 years and the mean number of core biopsies was 5.1 +/- .9. The concordance rates for histologic type, HG, ER, PR, and HER-2 status were 100%, 80.8%, 99%, 97.1%, and 86.5%, respectively.



CONCLUSIONS: Core biopsy can predict histologic type, HG, ER, PR and HER-2 status preoperatively in breast cancer when used properly.
MeSH terms
AdultBiopsy, NeedleBreast Neoplasms/metabolism*Breast Neoplasms/pathology*Breast Neoplasms/surgeryCarcinoma, Ductal, Breast/metabolism*Carcinoma, Ductal, Breast/pathology*FemaleHumansMiddle AgedPredictive Value of TestsPreoperative CareReceptor, erbB-2/analysisReceptors, Estrogen/analysisReceptors, Progesterone/analysisReproducibility of Results
DOI
10.1016/j.amjsurg.2007.11.024
PMID
18614146
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
AJOU Authors
김, 구상
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