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Immunohistochemical Analysis of the Expression of Cathepsin D in Human Gastric Adenocarninoma

Other Title
위선암의 Cathepsin D 발현에 대한 면역조직화학적 분석
한, 상욱; 주, 희재; 조, 용관; 이, 경포; 김, 명욱
Taehan Am Hakhoe chi, 29(1):93-102, 1997
Journal Title
Taehan Am Hakhoe chi; Journal of Korean Cancer Association; 대한암학회지
Cathepsin D의 발현은 모든 위선암환자에게서 정도의 차이는 있으나 100%에서 발견할

수 있어 위선암의 진행에 있어서 어떤 역할을 할 것이라는 추측을 할 수 있었고, 나이가 증

가할수록 더 강한 발현을 보여 cathepsin D의 발현은 에스트로젠 등의 호르몬의 영향을 받

고 있을 것이라는 추측을 하였다. 임상 및 병리학적인 예후 인자들과의 상관관계를 찾을 수

없었고 생존율에도 영향을 미치지 못함을 알 수 있어 위선암에 있어서 cathepsin D의 발현

양상은 예후인자로서의 의미는 없어 보인다고 사료된다. 그러나 암 조직의 변연에서 더 강

한 발현을 보인 환자에서 임파관 침습이 많이 동반되었고 재발율이 높았기에 cathepsin D는

위선암의 병리생리학적인 연구의 도구로서 사용될 가치가 있다고 생각된다.

Purpose : Cathepsin D is an acidic lysosomal proteinase involved in intracellular

protein turnover. Increased levels of this enzyme have been reported to be indicators of

aggressive tumor behavior in some human tumors. In gastric cancer, increased

expression of cathepsin D has been reported to be an independent prognostic factor.

Materials and Methods : We used standard immunohistochemical techniques on

formalin-fixed, paraffin-embedded tissues to examine the expression of the cathepsin D

in fifty five gastric adenocarcinomas. And we compared these with other indicators of

aggressive tumor behavior including stage of disease, tumor size, lymphatic invasion,

neural invasion, Lauren classification, disease recurrence and survival.

Results : Positive granular cytoplasmic staining for cathepsin D was detected in 100%

of the tumors and strongly positive staining was found in 53%. However, the intensity

of the staining varied from cell to cell in the same carcinoma tissue as well as among

samples. Positive staining also was seen in normal foveolar epithelial cells, parietal cells,

macrophages and ganglion cells. Our results did not show any correlation between the

expression of cathepsin D and other indicators of aggressive tumor behavior. But the

group having more intensely stained margins showed the tendency to frequent lymphatic


Conclusion : We conclude that the results obtained using polyclonal antibodies to

cathepsin D do not support the prognostic usefulness of immunohistochemical analysis of

this proteinase in tumor cells in human gastric adenocarcinoma, but this study may offer

some useful indicator for further pathophysiological studies on gastric adenocarcinoma.
Cathepsin DGastric adenocarcinomaPrognosisImmunohistochemical analysis
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