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Effectiveness of Gastrectomy in Stage Ⅳ Gastric Cancer with Hepatic Metastasis

Other Title
간전이의 제4기 위암에서 위절제술의 유용성
육, 정환 | 권, 성준 | 김, 병기 | 김, 병식 | 김, 성 | 노, 승무 | 목, 영재 | 박, 경규 | 박, 병주 | 박, 승만 | 박, 조현 | 방, 호윤 | 배, 재문 | 송, 영진 | 양, 두현 | 양, 대현 | 오, 성태 | 윤, 효영 | 이, 무송 | 이, 종인 | 조, 용관  | 최, 동욱 | 한, 상욱
Journal of Korean Cancer Association, 31(3). : 441-447, 1999
Journal Title
Journal of Korean Cancer Association
PURPOSE: The prognosis for patients with stage IV gastric cancer is very poor. However, recently, some studies have reported benefits from a gastric resection for metastatic gastric cancer. This clinical study was performed to evaluate the effectiveness of a noncurative gastrectomy in treating stage IV gastric cancer with hepatic metastasis.
MATERIALS AND METHODS: A retrospective analysis was performed on 98 gastric cancer patients who had undergone gastric resection, in spite of hepatic metastasis, between January 1990 and December 1996 at the Department of Surgery in 11 General Hospitals in Korea.
RESULTS: The average age was 58 years old, and the male-to-female ratio was 69: 29. The laboratory tests were unable to predict hepatic metastasis. In 54 cases, hepatic metastasis was not identified before the surgery. The most common location of gastric cancer was antrum (72 cases). The most common gross type was Bonmann type III (78 cases). The serosa-exposed cases were 80. The peritoneal seeding was combined in 17 cases. A total gastrectomy was performed in 18 cases and a distal gastrectomy in 80. Lymph-node dissection was performed in 23 Dl, and 51 D2 cases. Hepatic resection was performed in 36 cases, The frequent histologic types were moderately differentiated and poorly differentiated tubular adenocarcinoma. Postoperative adjuvant chemotherapy was done in 70 cases. The complication rate (7%) was low. The median survival time was 15 months, with mean survival time of 18 months. The 2-year and 3-year survival rates were 23%, and 7%, respectively. In the univariate analysis, good survival was closely related to limitation of hepatic metastasis to one lobe, a few metastases to both lobes, negativity of peritoneal seeding and lymph node dissection more than D2 (p<0.05),
CONCLUSIONS: An aggressive gastric resection for stage IV gastric cancer with hepatic metastasis might be beneficial in lengthening the survival period. A prospective study is needed, especiaUy one with an exact evaluation and analysis of the quality of life between the gastrectomy and nonresection groups.

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Journal Papers > School of Medicine / Graduate School of Medicine > Unclassified
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조, 용관  |  한, 상욱
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