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Prognostic Value of CEA and CAl9-9 in Serum and Peritoneal Washing Fluid in Gastric Carcinoma

Other Title
위암에서 혈청 및 복강 세척액의 CEA, CAl9-9치가 예후에 미치는 영향
Authors
한, 상욱; 조, 용관; 홍, 성우; 임, 영애; 곽, 연식; 김, 명욱
Citation
Taehan Am Hakhoe chi, 30(5):869-878, 1998
Journal Title
Taehan Am Hakhoe chi; Journal of Korean Cancer Association; 대한암학회지
ISSN
0496-6872
Abstract
Purpose : The clinical significance of preoperative serum levels of CEA and CAI 9-9,

levels of CEA and CA 19-9 in peritoneal washing fluid and free cancer cells in

peritoneal washing fluid in gastric cancer patients were evaluated in this study.

Materials and Methods : Serum and peritoneal levels of CEA and CAl9-9 and peritoneal

washing cytology in 115 patients with gastric cancer were analyzed with respect to the

prognostic factors using univariate and multivariate analysis.

Results : Positive rate of serum CEA and CAl9-9 was 16.5%, 13.0%. And that of

peritoneal washing CEA, CAl9-9 and cytology was 15.7%, 7.8% and 9.6%. A univariate

analysis showed that tumor markers in serum and peritoneal washing fluid and

peritoneal washing cytology had significant correlations with the progression of the

tumors, and Patients with positive serum or peritoneal tumor markers had poorer

survival after operation than did the patients with negative tumor markers. But in a

multivariate analysis showed that only peritoneal CA 19-9 was an independent risk

factor. And combination of these five markers provided more predictable prognostic

informations in a multivariate analysis.

Conclusion: Combination of serum or peritoneal levels of CEA, CAI 9-9 and washing

cytology appeared to be a useful marker for managing gastric cancer patients.
Keywords
CEACAI 9-9Washing cytologyGastric carcinoma
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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