Significant Correlation of Hepatocyte Growth Factor Level with Progression of Gastric Adenocarcinoma
위선암의 진행과 간세포성장인자와의 관련
한, 상욱; 이, 재호; 김, 욱환; 왕, 희정; 조, 용관; 김, 명욱
Taehan Am Hakhoe chi, 29(3):367-374, 1997
Taehan Am Hakhoe chi; Journal of Korean Cancer Association; 대한암학회지
Purpose: Hepatocyte growth factor(HGF) is a modulator of epithelial cell proliferation and motility. In this study, we measured the level of HGF in sera and tumor extracts of gastric adenocarcinoma using an enzyme-linked immunoassay and evaluated its association with tumor progression. Materials and Methods: The level of HGF in the sera of seventy-five patients with gastric adenocarcinoma and in the tumor extracts of forty-two tumors were examined in this study. The level of HGF was determined by an Immunis HGF EIA kit(Institute of Imrnunology). Results: The mean level of HGF in the sera of patients was 0.26+-0.19 ng/ml, which was significantly higher than in those of healthy controls(0.14+-0.07 ng/ml, p<0.05); the levels of HGF in the sera of patients increased according to the progression of the stage of cancer(p < 0.05). The mean level of HGF in tumor extracts was 8.22+- 9.27 ug/g protein, which was significantly higher than in those of healthy controls(1.95+-1.45 ug/g protein, p <0.05); the levels of HGF in the tumor extracts were correlated significantly with the progression of the tumor stage(p < 0.05). The mean level of HGF in the tumors of diffuse type was 11.28+-11.74 ug/g protein, which was significantly higher than in those of intestinal type(5.16+-4.31 ug/g protein, p<0.05). Conclusion: HGF may play an important role in the progression and differentiation of gastric adenocarcinoma.
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