Cited 0 times in Scipus Cited Count

Increased Expression of Phospholipase C-γ1 in Human Gastric Cancer Tissues

DC Field Value Language
dc.contributor.authorHwang, SC-
dc.contributor.authorHa, MJ-
dc.contributor.authorPark, KH-
dc.contributor.authorJoo, HJ-
dc.contributor.authorCho, YK-
dc.date.accessioned2011-11-28T06:45:38Z-
dc.date.available2011-11-28T06:45:38Z-
dc.date.issued1996-
dc.identifier.issn1226-3265-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4555-
dc.description.abstractPhospholipase C (PLC) plays a central role in signal transduction and is important in cellular growth, differentiation and transformation. There are currently ten known mammalian isozymes of PLC reported to date. However, their biological implication in carcinogenesis and in disease is not fully understood. Here we examined the relative content of various PLC isozymes present in 50 paired surgical specimens from human gastric cancer patients. Western blot analysis demonstrated considerablely higher levels of PLC-gl protein in gastric cancer tissues from 41 of 50 specimens as compared to that of normal mucosa. On immunohistochemistry, distinct speckles or clumps of PLC-gl staining were observed in the cytoplasms of primary malignant lesions as well as the invading cancer cell nests, in contrast to the normal tissues which were negative. Little differences in other isozymes were found. Only PLC-d1 was slightly increased in about two thirds of the patients, however, to a much lesser extent. In conclusion, although the causes of increased PLC-gl in gastric carcinomas remain to be explored further, the elevated level of PLC-gl suggests an altered signal transduction pathways in gastric carcinomas and may indicate an important role played by PLC-g1 in pathogenesis and proliferation of cancer cells.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.titleIncreased Expression of Phospholipase C-γ1 in Human Gastric Cancer Tissues-
dc.typeArticle-
dc.subject.keywordPLC-γ1-
dc.subject.keywordOver-expression-
dc.subject.keywordGastric carcinoma-
dc.contributor.affiliatedAuthor황, 성철-
dc.contributor.affiliatedAuthor하, 만준-
dc.contributor.affiliatedAuthor박, 광화-
dc.contributor.affiliatedAuthor주, 희재-
dc.contributor.affiliatedAuthor조, 용관-
dc.type.localJournal Papers-
dc.citation.titleAjou medical journal-
dc.citation.volume1-
dc.citation.number1-
dc.citation.date1996-
dc.citation.startPage68-
dc.citation.endPage75-
dc.identifier.bibliographicCitationAjou medical journal, 1(1). : 68-75, 1996-
dc.relation.journalidJ012263265-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Files in This Item:
Ajou medical journal_1(1)_68-75.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse