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The Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting

DC Field Value Language
dc.contributor.author박, 현희-
dc.contributor.author박, 관식-
dc.contributor.author이, 숙영-
dc.contributor.author조, 외경-
dc.contributor.author김, 재형-
dc.contributor.author김, 진수-
dc.contributor.author신, 동욱-
dc.date.accessioned2011-11-28T23:46:58Z-
dc.date.available2011-11-28T23:46:58Z-
dc.date.issued2006-
dc.identifier.issn0302-5780-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4567-
dc.description.abstractBACKGROUND: Postoperative nausea and vomiting (PONV) are common problems in patients undergoing a laparoscopic cholecystectomy. This study evaluated the effect of prophylactic metoclopramide (MCP) and induction with propofol on PONV.



METHODS: 165 patients undergoing laparoscopic cholecystectomy were randomly divided into four groups. Groups 1 (control group) and 2 were inducted with thiopental sodium. Groups 3 (propofol group) and 4 were inducted with propofol. Prophylactic metoclopramide 10 mg i.v. was administered in Groups 2 (MCP group) and 4 (propofol + MCP group). The incidence of PONV, the need for rescue antiemetics, adverse events, and the nausea severity scores were assessed at 0 to 1 hour and at 1 to 24 hours postoperatively.



RESULTS: During the first 24 hours after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 41.5%, 29.3%, 30.3% and 23.3%, respectively. There was no significant difference between the groups. During the period, 1 hour to 24 hours, after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 36.6%, 17.4%, 27.5% and 14.4%, respectively. The incidence of PONV in Group 4 was significantly lower than in Group 1 (P < 0.05).



CONCLUSIONS: In patients with laparoscopic cholecystectomy, a combination of prophylactic metoclopramide administration and induction with propofol was found to reduce the incidence of PONV by about 22.6% during the period 1 hour to 24 hours after anesthesia.
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dc.language.isoko-
dc.titleThe Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting-
dc.title.alternative마취 유도제로 사용한 Propofol과 예방적으로 투여한 Metoclopramide의 술 후 오심 및 구토에 미치는 영향-
dc.typeArticle-
dc.identifier.urlhttp://ekja.org/search.php?where=aview&id=10.4097%2Fkjae.2006.50.2.179&code=1011KJAE&vmode=AR-
dc.subject.keywordlaparoscopic cholecystectomy-
dc.subject.keywordmetoclopramide-
dc.subject.keywordpostoperative nausea and vomiting (PONV)-
dc.subject.keywordpropofol-
dc.contributor.affiliatedAuthor박, 관식-
dc.contributor.affiliatedAuthor이, 숙영-
dc.contributor.affiliatedAuthor김, 진수-
dc.type.localJournal Papers-
dc.identifier.doi10.4097/kjae.2006.50.2.179-
dc.citation.titleTaehan Mach'ikwa Hakhoe chi-
dc.citation.titleThe Journal of the Korean Society of Anesthesiologists-
dc.citation.title대한마취과학회지-
dc.citation.volume50-
dc.citation.number2-
dc.citation.date2006-
dc.citation.startPage179-
dc.citation.endPage183-
dc.identifier.bibliographicCitationTaehan Mach'ikwa Hakhoe chi, 50(2):179-183, 2006-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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