57 235

Cited 0 times in

Studies on the Prostaglandin Synthesis Stimulated by Bacterial Lipopolysaccharide in Mouse Peritoneal Macrophages

Other Title
마우스 복강 대식세포의 Prostaglandin 합성에 미치는 Bacteria Lipopolysaccharide의 영향
Authors
문, 창현; 김, 지영; 최, 소연; 박, 정미; 어, 수익; 이, 수환
Citation
Ajou medical journal, 1(1):138-145, 1996
Journal Title
Ajou medical journal; 아주의학
ISSN
1226-3265
Abstract
Production of inflammatory mediators by the host in response to bacterial lipopolysaccharide (LPS) is generally believed to be responsible for the pathogenesis of septic shock. One of the mediators associated with septic shock sequelae are arachidonic acid metabolites, including prostanoids and leukotrienes. Prostaglandin H synthase (PGHS) is a rate-limiting enzyme in prostanoid synthesis of which there were very recently reported two different isotypes. Their activities and expressions are known to be regulated by different mechanisms. Also, differences in response to stimulators have been shown for the different cell types. Even in the macrophage populations, there have been reported diverse profiles of prostanoid synthesis. These discrepancies might be due to the differences in the underlying regulation mechanisms, but presently, little information is available regarding these. Thus, in order to get insights into these discrepancies, firstly, we compared the characteristics of LPS-induced prostanoid production in alveolar macrophages and mouse peritoneal macrophages and secondly, we examined whether variations of glucose concentration affect LPS-induced prostanoid synthesis and PGHS-2 activity in both cell types. Overall responses to LPS were qualitatively similar between both cell types, and LPS-induced TXB2 production was attenuated in high glucose media.
Keywords
Peritoneal macrophageAlveolar macrophageBaterial lipopolysaccharideProstaglandin H synthase
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Files in This Item:
138-145.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse