49 146

Cited 0 times in

Occupational Asthma Caused by Serratial Peptidase and Lysozyme Chloride in a Pharmaceutical Industry

Authors
Park, HS; Nahm, DH
Citation
Ajou medical journal, 1(1):146-150, 1996
Journal Title
Ajou medical journal; 아주의학
ISSN
1226-3265
Abstract
There have been very few documented cases of occupational allergies caused by serratial lysozyme and peptidase. In this paper, we report a case of occupational asthma and rhinitis caused by Serratia( peptidase and lysozyme chloride which are used as anti-inflammatory agents. The patient had strong positive responses to peptidase and lysozyme extracts on skin-prick tests. Bronchoprovocation tests showed a dual asthmatic response to peptidase but only an early asthmatic response to lysozyme. Serum specific IgE antibodies to peptidase and lysozyme were detected by enzyme-linked immunosorbent assay (ELISA). In order to further characterize the allergenic component of these extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were also performed. Two IgE binding components (67, 10.9 kDa) were detected within the lysozyme extracts, and more than ten components ranging from 7.3 to 83.1 kDa found in peptidase extracts. The findings suggest that inhalation of peptidase and lysozyme can induce IgE-mediated bronchoconstriction in an exposed worker.
Keywords
PeptidaseLysozymeOccupational asthmaPharmaceutical industry
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
146-150.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse