Genotype Distribution of Hepatitis C Virus in Patients with Liver Disease
C형 간질환에서 C형 간염 바이러스 유전자형의 분포
조, 성원; 함, 기백; 김, 진홍; 이, 상인; 심, 찬섭
Ajou medical journal, 1(1):178-182, 1996
Ajou medical journal; 아주의학
It has been suggested that different genotypes have different clinical outcomes with regard to disease severity and response to interferon treatment. We studied the distribution of hepatitis C virus genotypes in 29 patients with liver disease by polymerase chain reaction with capsid - specific primers. Hepatitis C virus genotype lb(II) was present in 15 patients (51.7%), and 2a(III) in 6(20.6%). Five patients(17.2%) had evidence of dual infection(type lb(II) and type 2a(III)). Three patients were untypable by the method used. These data showed
that two genotypes, type lb(II) and 2a(III) account for most cases in our cohort of patients with a relatively higher frequency of typelb(II).
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