Giant aneurysms present challenging problems with conventional techniques because the lesion is in a difficult area or lacks a definitive aneurysmal neck. For the safety of operation and protection from cerebral ischemia, deep hypothermic circulatory arrest and cerebral protection with barbiturate is considered a useful technique. But deep hypothermia may produce myocardial depression and coagulopathy with high mortality. We report our experience with cardiopulmonary bypass with deep hypothermic circulatory arrest for the management of a patient with giant aneurysm of basilar artery and mild coronary artery stenosis. No significant complications were related to the technique of cardiopulmonary bypass with deep hypothermic circulatory arrest.