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Effect of Anti-idiotype Antibody on Anti-DNA Antibody Production by Hybridoma Cells

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dc.contributor.author박, 선-
dc.contributor.author김, 형일-
dc.contributor.author이, 미리나-
dc.contributor.author김, 영태-
dc.contributor.author윤, 정구-
dc.contributor.author김, 주덕-
dc.date.accessioned2011-12-01T04:26:49Z-
dc.date.available2011-12-01T04:26:49Z-
dc.date.issued1997-
dc.identifier.issn1015-6453-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4629-
dc.description.abstractAnti-idiotype antibody (anti-id Ab) which recognizes idiotope in the variable region of immunoglobulin (Ig) can regulate Ab production by B cells in vivo and in vitro.

Although it has been reported that anti-id Ab can suppress IgM production by

lymphocytes or hybridoma cells without suppression of cell proliferation, the regulatory mechanism of anti-id Ab is not completely understood.

We studied the effects of anti-id Ab on the production of IgG class anti-DNA Ab by

hybridoma cells, on the proliferation of cells, and on the transcription levels of Ig genes.

In contrast to suppressive effect of anti-id Ab on the production of IgM previously

reported by others, stimulatory effects of anti-id Ab on the production of IgG by

hybridoma cells as well as the proliferation of these cells were observed. However, little effect of anti-id Ab on the transcription levels of Ig genes was observed.

These results suggest that anti-id Ab can increase Ab production by stimulation of

cell proliferation. Furthermore, these results suggest that the effect of anti-id Ab on the

production of Ab may be determined by the difference in class of Ab produced by

hybridoma cells following the treatment with anti-id Ab.
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dc.language.isoko-
dc.titleEffect of Anti-idiotype Antibody on Anti-DNA Antibody Production by Hybridoma Cells-
dc.title.alternative항이디오타입 항체가 하이브리도마 세포의 항DNA 항체 생산에 미치는 영향-
dc.typeArticle-
dc.subject.keywordAnti-idiotype antibody-
dc.subject.keywordIsotype-
dc.subject.keywordAb production-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of immunology-
dc.citation.volume19-
dc.citation.number4-
dc.citation.date1997-
dc.citation.startPage513-
dc.citation.endPage524-
dc.identifier.bibliographicCitationKorean journal of immunology, 19(4). : 513-524, 1997-
dc.relation.journalidJ010156453-
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Journal Papers > School of Medicine / Graduate School of Medicine > Unclassified
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