High Dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation
Kim, HS; Cho, YH; Song, YG; Park, JW; Kim, HC
Ajou medical journal, 1(1):344-348, 1996
Ajou medical journal; 아주의학
High-dose chemotherapy with autologous stem cell support is a new therapeutic modality for otherwise incurable malignancy. Peripheral blood stem cell(PBSC) is considered an excellent stem cell source alternative to bone marrow after myeloablative cytotoxic treatment.
We treated 7 patients with malignant disease (5 lymphomas, one gastric carcinoma and one undifferentiated cancer) with high-dose chemotherapy followed by autologous peripheral stem cell support at Ajou University Hospital.
All patients tolerated high-dose chemotherapy and reinfusion of PBSC well. Hematologic recovery was rapid and sustained. The response to high-dose chemotherapy was significantly improved as compared with that to prior conventional chemotherapy and /or radiotherapy, to which they had become refractory.
We confirm the feasibility and value of collection and reinfusion of PBSC in conjunction with the high-dose chemotherapy.
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