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High Dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation

Authors
Kim, HS; Cho, YH; Song, YG; Park, JW; Kim, HC
Citation
Ajou medical journal, 1(1):344-348, 1996
Journal Title
Ajou medical journal; 아주의학
ISSN
1226-3265
Abstract
High-dose chemotherapy with autologous stem cell support is a new therapeutic modality for otherwise incurable malignancy. Peripheral blood stem cell(PBSC) is considered an excellent stem cell source alternative to bone marrow after myeloablative cytotoxic treatment.

We treated 7 patients with malignant disease (5 lymphomas, one gastric carcinoma and one undifferentiated cancer) with high-dose chemotherapy followed by autologous peripheral stem cell support at Ajou University Hospital.

All patients tolerated high-dose chemotherapy and reinfusion of PBSC well. Hematologic recovery was rapid and sustained. The response to high-dose chemotherapy was significantly improved as compared with that to prior conventional chemotherapy and /or radiotherapy, to which they had become refractory.

We confirm the feasibility and value of collection and reinfusion of PBSC in conjunction with the high-dose chemotherapy.
Keywords
High-dose chemotherapyPeripheral blood stem cell transplantation
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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