A Prospective Comparative Study of Monocid and Cefotiam as a Prophylactic Antibiotics in Plastic Surgery

Abstract

Monocid´ (cefonicid) is a new second-generation cephalosporin with a prolonged half life which can offer a numerous therapeutic advantages.as prophylactic antibiotics in plastic and reconstructive Surgery. Prospective comparative study using monocid and cefotiam for prophylaxis against postopertive wound infection was carried out in each 30 patients (total 60) undergoing plastic and reconstructive surgery. Monocid, which has an extended serum half-life, was administered once daily, while cefotiam was given every six hours. No evidence of postoperative wound infection was observed in any of the patients who met the criteria for evaluation. Adverse reaction consisted mainly of infrequent gastrointestinal symptom and laboratory abnormalities was not observed in this study. No differences between the two regimens were found with respect to safety or efficacy in the prevention of postopertive infection in elective and emergency plastic and reconstructive surgical procedures. The effectiveness of once-daily administration should make mononcid a highly cost-effective alternative to many of the other expensive cephalosporin.