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Studies on Ly-1+B Cells in Autoimmune-prone Strain of MRL/lpr Mice

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dc.contributor.authorJang, YJ-
dc.contributor.authorYoun, JK-
dc.contributor.authorPark, JS-
dc.contributor.authorKim, YT-
dc.description.abstractLy-1 antigen is a surface antigen of murine T cells and is also expressed on the membrane of certain B cell population, especially the B cells in the peritoneal cavity of mice. Ly-1 antigen is the same molecule of CD5 antigen expressed on human T cells and a certain population of human B cells. It is suggested that Ly-l^(+)B cells are possibly involved in the pathogenesis of autoimmune diseases. In the present work, we analysed the profiles of the distribution of Ly-1^(+)B cells in the autoimmune-prone strain of MRL/1pr mice with different ages and normal mice (BALB/c and C57BL/6), because most of the studies for exploring the role of Ly-1^(+)B cells in the pathogenesis of autoimmune diseases have been carried out by using autoimmune-prone NZB-related mice. Two-parameter FACS analysis was used to investigate the percentage of Ly-1^(+)B cell subpopulation in spleens and peritoneal cavities of normal mice and autoimmune-prone MRL/1pr mice with different ages. It is shown that Ly-1^(+)B cell subpopulations in spleens and peritoneal cavities are present in increased number in MRL/lpr mice, suggesting an important role of Ly-1^(+)B cells in autoimmunity. In addition, older MRL/lpr mice showed higher number of Ly-1^(+)B cells as compared with those of young MRL/1pr mice.en
dc.titleStudies on Ly-1+B Cells in Autoimmune-prone Strain of MRL/lpr Mice-
dc.subject.keywordLy-1^(+)B cells-
dc.subject.keywordAutoimmune disease-
dc.subject.keywordFACS analysis-
dc.contributor.affiliatedAuthor장, 영주-
dc.contributor.affiliatedAuthor윤, 정구-
dc.type.localJournal Papers-
dc.citation.titleAjou medical journal-
dc.identifier.bibliographicCitationAjou medical journal, 2(1). : 40-45, 1997-
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Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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