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Comparative Study on the Sensitivities and Specificities of CT and Camera Based PET Scan in Determination of Lung Cancer Staging

Other Title
폐암의 병기결정에 있어서 컴퓨터 단층촬영(CT)과 감마 카메라를 이용한 양전자방출 단층촬영(PET)의 민감도와 특이도의 비교연구
Authors
문, 광덕; 이, 철주; 김, 영진; 최, 호; 김, 정태; 강, 준규; 홍, 준화; 박, 찬희; 윤, 석남
Citation
Ajou medical journal, 4(1):52-57, 1999
Journal Title
Ajou medical journal; 아주의학
ISSN
1226-3265
Abstract
A retrospective study was undertaken to compare sensitivities and specificities of computed tomography (CT) scan and radiolabeled glucose analog 18F-fluoro-2-deoxy-D-glucose (FDG) camera based positron emission tomography (PET).

Nine patients with lung cancer who underwent preoperative CT and 18F-FDG coincidence PET scanning were evaluated retrospectively. Imaging studies were read prospectively and blinded to the surgical and pathologic data. The final diagnosis was established by histopathologic examination at thoracotomy.

CT was accurate in 7 patients (77.8%), with understaging in 1 patient and overstaging in 1 patient. In´ detection of locally advanced disease (N2/N3), the sensitivity, specificity, positive predictive value and negative predictive value were 50%, 85.7%, 50% and 85.7%, respectively. On the other hand, ´$F-FDG-PET was accurate in 8 patients (88.9%), with overstaging in 1 patient and without any understaging. In detection of locally advanced disease (N2/N3), the sensitivity, specificity, positive predictive value and negative predictive value were 100%, 85.7%, 66.7% and 100%, respectively.

18F-FDG-PET was significantly more accurate than CT in lymph node staging of lung cancer. The high negative predictive value of FDG-PET could reduce a need for invasive surgical staging (ISS). (Ajou Med J 1999; 4(1): 52-57)
Keywords
Positron emission tomography (PET)
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Thoracic & Cardiovascular Surgery
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