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Prediction of Histologic Grade and Multidrug Resistance of Brain Tumors Using Brain SPECT

Other Title
핵영상을 이용한 뇌종양의 악성도 및 Multidrug Resistance 예측에 관한 연구
허, 지순; 조, 경기; 김, 기용; 안, 영환; 안, 영민; 윤, 수한; 조, 기홍; 박, 찬희
Taehan Sinkyŏng Oekwa Hakhoe chi, 31(3):222-229, 2002
Journal Title
Taehan Sinkyŏng Oekwa Hakhoe chi; Journal of Korean Neurosurgical Society; 대한신경외과학회지
Objective:Computerized tomography(CT) and magnetic resonance imaging(MRI) are very useful in detection of structural change in the brain including tumors. However, they can not inform functional and biological behavior of such lesions. 99mTc-Methoxyisobutyl isonitrile(MIBI) is considered as a substrate for MDR1 gene-encoded permeability glycoprotein(P-gp) and it has been used in the evaluation of multidrug resistance(MDR) in various tumors. The purpose of the study is to demonstrate the presence of MDR in brain tumor and brain tumor grading by an external imaging with 201Thallium and 99mTc-MIBI SPECT.

Methods:201Thallium and 99mTc-MIBI SPECT were performed in 18 patients with malignant tumors and in six patients with benign tumors. Immunohistochemical staining(IHC) of the tumor specimen for P-gp was also performed. The histologic grading of the tumors and immunohistochemical staining for P-gp were compared to the dual brain SPECT findings of 201Thallium and 99mTc-MIBI SPECT studies. Brain tumor with positive 201Thallium SPECT and negative 99mTc-MIBI SPECT is considered to be multidrug resistance. An uptake index obtained from brain SPECT was used for tumor grading. MDR1 gene-encoded P-gp was assessed by immunohistochemical staining using a monoclonal antibody for P-gp.

Results:The malignant group showed significantly higher uptake indices in the 201Thallium and 99mTc-MIBI SPECT than benign group. The uptake index of 99mTc-MIBI SPECT was inversely correlated with P-gp immunohistochemical staining without statistical significance.

Conclusion:201Thallium and 99mTc-MIBI SPECT are useful for predicting histologic grade of brain tumors, and 99mTc-MIBI SPECT might be useful for predicting the presence of MDR protein.
Biological activityBrain tumorMultidrug resistanceproteinP-glycoprotein99mTc-MIBI SPECT201Thallium SPECT
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Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
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