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In Vitro Blood-brain Barrier Model of Astrocyte and Endothelial Monolayer Co-culture Using Collagen-coated Microporous Membrane

Other Title
정상 성상세포와 혈관 내막세포를 공막 분리 동시 배양으로 구축한 체외혈뇌장벽 모델
Authors
윤, 수한; 조, 기홍; 김, 세혁; 안, 영환; 안, 영민; 조, 경기; 최, 중언
Citation
Taehan Sinkyŏng Oekwa Hakhoe chi, 26(5):617-624, 1997
Journal Title
Taehan Sinkyŏng Oekwa Hakhoe chi; Journal of Korean Neurosurgical Society; 대한신경외과학회지
ISSN
1225-8245
Abstract
There are three types of the in vitro blood-brain barrier models that are endothelial monolayer, astrocyte and endothelial monolayer co-culture, and benign glioma and endothelial monolayer co-culture. We made these three types of models and evaluated permeability ratio for four molecular weight(MW 373, 4400, 9300, 38900) and electrical resistance of endothelial monolayer in each type. Astrocyte and endothelial monolayer co-culture showed the lowest permeability ratio and highest electrical resistance among them and that suggested astrocyte and endothelial monolayer co-culture was best for the in-vitro blood-brain barrier model.
Keywords
Endothelial monolayerCoculture systemBlood-brain barrier
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
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