Expression of neuropeptide in psoriasis in relation to aggravation of symptoms
건선의 악화에 따른 신경펩티드의 발현변화
장, 용현; 이, 은소
Taehan P'ibu Yŏn'gu Hakhoe chi, 11(2):41-48, 2004
Taehan P'ibu Yŏn'gu Hakhoe chi; Korean journal of investigative dermatology; 대한피부연구학회지
Many clinical evidences suggest the components of nervous system including psychological and neurogenic factors can influence the course of psoriasis. However, the nature of the association between stress and psoriasis remains unclear, in part due to the lack of substantial evidence regarding the participation of cutaneous neurogenic factors in the pathogenesis of psoriasis. To examine the role of neurogenic factors such as neuropeptides in aggravation of psoriasis. We used immunohistochemistry to detect the expression of substance P(SP), nerve growth factor(NGF) and a neuropeptide degrading enzyme such as neutral endopeptidase(NEP) in the lesional skin of psoriasis patients(n=10) and compared them with skin of normal control (n=8). The concentrations of SP and calcitonin gene related peptide(CGRP) in psoriasis patients(n=8) were also measured by enzyme-linked immunosorbent assay and were compared with those of normal controls(n=8). When compared with normal skin, lesional skin of psoriasis patients showed the following characteristic features: (I) strong immunoreactivity for SP and nerve growth factor(NGF) throughout the epidermis and papillary dermis; (ii) increased expression of neutral endopeptidase in the papillary dermis. The difference in the serum concentration of SP in the psoriasis group compared with that in the control group was not significant(P=0.13). However, the serum concentration of CGRP in the psoriasis group was significantly lower than that in the control group(P= 0.001). Therefore, the elevated immunoreactivity of SP, NGF and NEP accompanied with the decreased serum levels of CGRP may play important roles in the pathogenesis of psoriasis.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,931,185
Total Download :1,184,782
Today View :1,082
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.