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Gene Expression of NeuroD/BETA2 during Development of the Mouse Central Nervous System

Authors
Cho, JH; Hwang, WS; Kim, YS; Lee, YD; Suh-Kim, H
Citation
Taehan Haebu Hakhoe chi, 33(1):13-19, 2000
Journal Title
Taehan Haebu Hakhoe chi; The Korean journal of anatomy; 대한해부학회지
ISSN
1225-1305
Abstract
NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play

a role in terminal differentiation during neurogenesis. To gain further insight into the

function of NeuroD/BETA2 in the nervous system development, we examined the

expression pattern of NueroD/BETA2 during embryonic and postnatal development by in

situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the

developing nervous system. Gene expression of the NeuroD/BETA2 in developing

cerebellum and hippocampus increased during the embryonic stages and persisted

throughout postnatal development and remained at a stable level in the adult brain.

NeuroD/BETA2 expression was detected in postmitotic cells in the subventricular zone

of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2

may role in terminal differentiation during neurogenesis.
Keywords
NeuroDBETA2BrainMouse생쥐
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Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
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